Open Cluster Characterization via Cross-Correlation with Spectral Library

We present a characterization method based on spectral cross-correlation to obtain the physical parameters of the controversial stellar aggregate ESO442-SC04. The data used was obtained with GMOS at Gemini-South telescope including 17 stars in the central region of the ob ject and 6 standard-stars. FXCOR was used in an iterative process to obtain self-consistent radial velocities for the standard-stars and averaged radial velocities for the science spectra. Spectral types, effective temperature, suface gravity and metallicities parameters were determined using FXCOR to correlate cluster spectra with ELODIE spectral library and selecting the best correlation matches using the Tonry and Davis Ratio (TDR). Analysis of the results suggests that the stars in ESO442-SC04 are not bound and therefore they do not constitute a physical system.Comment: 4-page paper from IAU symposium 266. Contains 3 eps figures and IAU document class file 'iau.cls

Open clusters or their remnants: B and V photometry of NGC 1901 and NGC 1252

Photometry in the B and V bands is presented for the southern stellar groups NGC 1901 and NGC 1252. NGC 1901 is often described as an open cluster while NGC 1252 consists of a concentration of about 20 stars centered approx 20' north of the original New General Catalogue coordinates, and at the southwest edge of the large region previously assigned to this object in the literature. NGC 1901 has a clear main sequence and shares similarities with the Hyades. We derive a reddening value E(B-V) = 0.04, a distance from the Sun d = 0.45 kpc (Z = -0.23 kpc) and an age 0.6 +/- 0.1 Gyr. NGC 1901 is conclusively a physical system, dynamically comparable to or more evolved than the Hyades. The colour- magnitude diagram of NGC 1252 suggests a turnoff and main sequence, and a total of 12 probable members. We simulated the Galactic field colour-magnitude diagram in the same direction and found it to be a poor match to NGC 1252, suggesting that NGC 1252 is not a field fluctuation. Isochrone fitting to the probable members is consistent with E(B-V) = 0.02, a distance from the Sun d = 0.64 kpc (Z = -0.46 kpc) and an age 3 +/- 1 Gyr. NGC 1252 cannot be ruled out as a physical group with the available data. If so, evidence is found that it is not a classical open cluster, but rather an open cluster remnant.Comment: 25 pages, 11 Postscript figures, accepted for A&

Association of Plasma 25â Hydroxyvitamin D Concentrations and Pathogenic Oral Bacteria in Postmenopausal Females

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141146/1/jper0944.pd

Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs)

BACKGROUND: Studies conducted in the USA have demonstrated that micronutrients such as folate and vitamin B12 play a significant role in modifying the natural history of high-risk human papillomaviruses (HR-HPVs), the causative agent for developing invasive cervical cancer (CC) and its precursor lesions. OBJECTIVE: The purpose of the current study was to investigate whether these micronutrients have similar effects on HR-HPV infections in Indian women. METHODS: The associations between serum concentrations of folate and vitamin B12 and HR-HPV infections were evaluated in 724 women who participated in a CC screening study in the southern state of Andhra Pradesh, India. Serum folate and vitamin B12 concentrations were measured by using a competitive radio-binding assay. Digene hybrid capture 2 (HC2) assay results were used to categorize women into two groups, positive or negative for HR-HPVs. Unconditional logistic regression models specified a binary indicator of HC2 (positive/negative) as the dependent variable and serum folate concentrations combined with serum vitamin B12 concentrations as the independent predictor of primary interest. Models were fitted, adjusting for age, education, marital status, parity, type of fuel used for cooking and smoking status. RESULTS: Women with higher concentrations of serum folate (>6 ng/mL) and vitamin B12 (>356 pg/mL) were at lower risk of being positive for HR-HPVs compared to those with serum folate ≤6 ng/mL and serum vitamin B12 ≤ 356 pg/mL (odds ratio = 0.26; 95% confidence interval: 0.08-0.89; P = 0.03). CONCLUSIONS: These results demonstrated that improving folate and vitamin B12 status in Indian women may have a beneficial impact on the prevention of CC. Micronutrient based interventions for control of HR-HPV infections may represent feasible alternatives to vaccine based approaches to HPV disease prevention, which are currently unaffordable for use in resource limited areas in rural India

Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection?

Indexación: Web of Science.Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. cruzi Calreticulin (TcCRT), an endoplasmic reticulum-resident chaperone, translocated-externalized by the parasite, may mediate at least an important part of this effect. Thus, recombinant TcCRT (rTcCRT) has important in vivo antiangiogenic and antitumor activities. However, the relevant question whether the in vivo antitumor effect of T. cruzi infection is indeed mediated by the native chaperone (nTcCRT), remains open. Herein, by using specific modified anti-rTcCRT antibodies (Abs), we have neutralized the antitumor activity of T. cruzi infection and extracts thereof, thus identifying nTcCRT as a valid mediator of this effect. Methods: Polyclonal anti-rTcCRT F(ab')(2) Ab fragments were used to reverse the capacity of rTcCRT to inhibit EAhy926 endothelial cell (EC) proliferation, as detected by BrdU uptake. Using these F(ab')(2) fragments, we also challenged the capacity of nTcCRT, during T. cruzi infection, to inhibit the growth of an aggressive mammary adenocarcinoma cell line (TA3-MTXR) in mice. Moreover, we determined the capacity of anti-rTcCRT Abs to reverse the antitumor effect of an epimastigote extract (EE). Finally, the effects of these treatments on tumor histology were evaluated. Results: The rTcCRT capacity to inhibit ECs proliferation was reversed by anti-rTcCRT F(ab')(2) Ab fragments, thus defining them as valid probes to interfere in vivo with this important TcCRT function. Consequently, during infection, these Ab fragments also reversed the in vivo experimental mammary tumor growth. Moreover, anti-rTcCRT Abs also neutralized the antitumor effect of an EE, again identifying the chaperone protein as an important mediator of this anti mammary tumor effect. Finally, as determined by conventional histological parameters, in infected animals and in those treated with EE, less invasive tumors were observed while, as expected, treatment with F(ab')(2) Ab fragments increased malignancy. Conclusion: We have identified translocated/externalized nTcCRT as responsible for at least an important part of the anti mammary tumor effect of the chaperone observed during experimental infections with T. cruzi.http://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2764-

The role of the right temporoparietal junction in perceptual conflict: detection or resolution?

The right temporoparietal junction (rTPJ) is a polysensory cortical area that plays a key role in perception and awareness. Neuroimaging evidence shows activation of rTPJ in intersensory and sensorimotor conflict situations, but it remains unclear whether this activity reflects detection or resolution of such conflicts. To address this question, we manipulated the relationship between touch and vision using the so-called mirror-box illusion. Participants' hands lay on either side of a mirror, which occluded their left hand and reflected their right hand, but created the illusion that they were looking directly at their left hand. The experimenter simultaneously touched either the middle (D3) or the ring finger (D4) of each hand. Participants judged, which finger was touched on their occluded left hand. The visual stimulus corresponding to the touch on the right hand was therefore either congruent (same finger as touch) or incongruent (different finger from touch) with the task-relevant touch on the left hand. Single-pulse transcranial magnetic stimulation (TMS) was delivered to the rTPJ immediately after touch. Accuracy in localizing the left touch was worse for D4 than for D3, particularly when visual stimulation was incongruent. However, following TMS, accuracy improved selectively for D4 in incongruent trials, suggesting that the effects of the conflicting visual information were reduced. These findings suggest a role of rTPJ in detecting, rather than resolving, intersensory conflict

Spatial dependence of 2MASS luminosity and mass functions in the old open cluster NGC 188

Luminosity and mass functions in the old open cluster NGC 188 are analysed by means of J and H 2MASS photometry. Within the uncertainties, the observed projected radial density profile of NGC 188 departs from the two-parameter King model in two inner regions, which reflects the non-virialized dynamical state and possibly, some degree of non-sphericity in the spatial shape of this old open cluster. Fits with two and three-parameter King models to the radial distribution of stars resulted in a core radius of 1.3 pc and a tidal radius of 21 pc. The present 2MASS analysis resulted in significant slope variations with distance in the mass function $\phi(m)\propto m^{-(1+\chi)}$, being flat in the central parts ($\chi=0.6\pm0.7$) and steep in the cluster outskirts ($\chi=7.2\pm0.6$). The overall mass function has a slope $\chi=1.9\pm0.7$, slightly steeper than a standard Salpeter mass function. Solar metallicity Padova isochrone fits to the near-infrared colour-magnitude diagram of NGC 188 resulted in an age of $7.0\pm1.0$ Gyr. The best fit, obtained with the 7.1 Gyr isochrone, produced a distance modulus \mM=11.1\pm0.1, \ebv=0.0, and a distance to the Sun \ds=1.66\pm0.08 kpc. The observed stellar mass (in the range 0.98 \ms - 1.08 \ms) in NGC 188 is \mobs=380\pm12 \ms. A simple extrapolation of the observed overall mass function to stars with 0.08 \ms resulted in a total present mass of \mtot\sim(1.8\pm0.7)\times10^4 \ms. On the other hand, for a more realistic initial mass function which flattens in the low-mass range, the total mass in NGC 188 drops to \mtot\sim(3.8\pm1.6)\times10^3 \ms.Comment: 13pages and 12 figures. Astronomy and Astrophysics, accepte

Keeping in Touch with One's Self: Multisensory Mechanisms of Self-Consciousness

BACKGROUND: The spatial unity between self and body can be disrupted by employing conflicting visual-somatosensory bodily input, thereby bringing neurological observations on bodily self-consciousness under scientific scrutiny. Here we designed a novel paradigm linking the study of bodily self-consciousness to the spatial representation of visuo-tactile stimuli by measuring crossmodal congruency effects (CCEs) for the full body. METHODOLOGY/PRINCIPAL FINDINGS: We measured full body CCEs by attaching four vibrator-light pairs to the trunks (backs) of subjects who viewed their bodies from behind via a camera and a head mounted display (HMD). Subjects made speeded elevation (up/down) judgments of the tactile stimuli while ignoring light stimuli. To modulate self-identification for the seen body subjects were stroked on their backs with a stick and the felt stroking was either synchronous or asynchronous with the stroking that could be seen via the HMD. We found that (1) tactile stimuli were mislocalized towards the seen body (2) CCEs were modulated systematically during visual-somatosensory conflict when subjects viewed their body but not when they viewed a body-sized object, i.e. CCEs were larger during synchronous than during asynchronous stroking of the body and (3) these changes in the mapping of tactile stimuli were induced in the same experimental condition in which predictable changes in bodily self-consciousness occurred. CONCLUSIONS/SIGNIFICANCE: These data reveal that systematic alterations in the mapping of tactile stimuli occur in a full body illusion and thus establish CCE magnitude as an online performance proxy for subjective changes in global bodily self-consciousness